As the subject line states - backup your QuickPlay configuration (Utilities --> Backup/Restore)
I have been using QuickPlay for a long time and this Backup option has saved me countless hours of work numerous times, however, let me tell you about a time that dummy me didn't use it and not using it it cost me time, energy and aggravation (through no fault of QuickPlay - my own stupidity!!)
I have quite a number of systems in my QuickPlay list (38). I also have all of my games in one main list. I am constantly tweaking my ROMs list (some say that I have OCD but that's a story for another day!)

So, the moral of this story is (and anyone that plays RPG games will be very familiar with this moral) - back up and back up often.
On a similar note, how difficult would it be to implement a prompt asking "are you sure that you want to clear the ROM list?" when selecting the Clear the ROM list option? This could be a safety net for knuckleheads like me that don't always save their work.
Jason